Caulobacter crescentus cell poles are microenvironments in which protein interactions and other chemical reactions are reactions are concentrated and controlled in a space that is separate from the surrounding cytoplasm. Using our growing knowledge of the PopZ polar assembly scaffolding protein, its binding partners, and the organization of proteins within this complex network, will it be possible to re-engineer this microenvironment to perform novel functions?

PopZ networks in vitro

PopZ networks in vivo

Luis Comolli, LBNL

Luis Comolli, LBNL

Luis Comolli, LBNL